α-Halo carbonyls enable meta selective primary, secondary and tertiary C-H alkylations by ruthenium catalysis was written by Paterson, Andrew J.;Heron, Callum J.;McMullin, Claire L.;Mahon, Mary F.;Press, Neil J.;Frost, Christopher G.. And the article was included in Organic & Biomolecular Chemistry in 2017.Recommanded Product: 2-(m-Tolyl)pyridine This article mentions the following:
A catalytic meta selective C-H alkylation of arenes is described using a wide range of α-halo carbonyls as coupling partners. Previously unreported primary alkylations with high meta selectivity have been enabled by this methodol. whereas using straight chain alkyl halides affords ortho substituted products. Mechanistic anal. reveals an activation pathway whereby cyclometalation with a ruthenium(II) complex activates the substrate mol. and is responsible for the meta selectivity observed A distinct second activation of the coupling partner allows site selective reaction between both components. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Recommanded Product: 2-(m-Tolyl)pyridine).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 2-(m-Tolyl)pyridine