Ligand-Promoted Meta-C-H Arylation of Anilines, Phenols, and Heterocycles was written by Wang, Peng;Farmer, Marcus E.;Huo, Xing;Jain, Pankaj;Shen, Peng-Xiang;Ishoey, Mette;Bradner, James E.;Wisniewski, Steven R.;Eastgate, Martin D.;Yu, Jin-Quan. And the article was included in Journal of the American Chemical Society in 2016.Quality Control of (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester This article mentions the following:
The authors report the development of a versatile 3-acetylamino-2-hydroxypyridine class of ligands that promote meta-C-H arylation of anilines, heterocyclic aromatic amines, phenols, and 2-benzyl heterocycles using norbornene as a transient mediator. More than 120 examples are presented, demonstrating this ligand scaffold enables a wide substrate and coupling partner scope. Meta-C-H arylation with heterocyclic aryl iodides as coupling partners is also realized for the first time using this ligand. The utility for this transformation for drug discovery is showcased by allowing the meta-C-H arylation of a lenalidomide derivative The first steps toward a silver-free protocol for this reaction are also demonstrated. In the experiment, the researchers used many compounds, for example, (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1Quality Control of (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester).
(2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester (cas: 209798-48-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of (2-Chloro-pyridin-3-yl)-carbamic acid tert-butyl ester