Synthesis and pharmacological activity of some 3-amino-11H-indolo[3,2-c][1,8]naphthyridines was written by Da Settimo, A.;Primofiore, G.;Biagi, G.;Santerini, V.. And the article was included in Farmaco, Edizione Scientifica in 1976.SDS of cas: 1075-62-3 This article mentions the following:
The pyridines I (R = H, Ac) were cyclized and the naphthyridine II (X = O) treated with 4,2-RR1C6H3NHNH2 (R = H, F, Cl, Br, Me, R1 = H; R = H, R1 = Cl, Me, MeO) to give II (X = 4,2-RR1C6H3NHN), which were cyclized with HCl to give the indolonaphthyridines III. III were also prepared directly by treating II (X = O) with 4,2-RR1C6H3NHNH2 and HCl. 2,6-Diaminopyridine was treated with β-propiolactone to give I (R = HO2CCH2CH2) which was cyclized and the product dehydrogenated to give anthyridinedione IV. At 50 mg/kg III (R = F, R1 = H) reduced delayed hypersensitivity, but was toxic. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3SDS of cas: 1075-62-3).
N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. SDS of cas: 1075-62-3