Syntheses of the piperidine alkaloids (±)-cassine, (±)-spectaline, (±)-spicigerine methyl ester and of (±)-azimic acid and (±)-carpamic acid was written by Hasseberg, Hans Albrecht;Gerlach, Hans. And the article was included in Liebigs Annalen der Chemie in 1989.Formula: C5H3Br2NO This article mentions the following:
The title compounds I, II, III, IV (n = 5, 7), resp., were prepared from 2,6-dibromo-3-pyridinol via coupling of the pyridine V with Grignard agents in presence of dichloro[bis(diphenylphosphino)propane]nickel. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Formula: C5H3Br2NO).
2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C5H3Br2NO