Pd-catalyzed cross-coupling reactions with carbonyls: application in a very efficient synthesis of 4-aryltetrahydropyridines was written by Barluenga, Jose;Tomas-Gamasa, Maria;Moriel, Patricia;Aznar, Fernando;Valdes, Carlos. And the article was included in Chemistry – A European Journal in 2008.Computed Properties of C10H17NO2 This article mentions the following:
Readily available 4-piperidones are directly employed in a very efficient Pd-catalyzed synthesis of 4-aryltetrahydropyridines, which are important scaffolds in medicinal chem. The actual coupling partner, a tosylhydrazone, is generated in situ from the piperidone and tosylhydrazine. The reaction can be applied to other ketones and aldehydes, providing polysubstituted olefins directly from carbonyls by a very simple and efficient procedure. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C10H17NO2