Kinetic study on the conversion of pyridine- and quinolinecarboxylic acids to the corresponding trichloromethyl compounds was written by Takahashi, Kazuyuki;Takeda, Koichi;Mitsuhashi, Keiryo. And the article was included in Journal of Heterocyclic Chemistry in 1978.Formula: C7H6N2 This article mentions the following:
The apparent 2nd order rate constant of the conversion of substituted picolinic and quinaldinic acids to the corresponding trichloromethylpyridines and quinolines by treatment with PCl5 in refluxing SOCl2 was measured. The logarithms of the rate constants (log k) are linear with the basicities (pKa) of the unsaturated ring nitrogens in the substrates. The reaction constant ρ was estimated In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Formula: C7H6N2).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C7H6N2