A novel synthetic scheme for 2-ethylthioisonicotinamide was written by Wang, Cheng-Hsia;Hwang, Fang-Yu;Horng, Jhy-Ming;Chen, Chao-Tung. And the article was included in Heterocycles in 1979.Quality Control of 2-Isopropylpyridine This article mentions the following:
The title compound was prepared by successive ammoxidation of 4-picoline, ethylation of 4-cyanopyridine with Et radicals generated by decarboxylation of EtCO2H, and treatment of 2-ethylisonicotinonitrile with (NH4)2S. A laboratory ammoxidation apparatus is described. Pyridine was alkylated to its 2- and 4-alkyl derivatives and 4-cyanopyridine to its 2-alkyl and 2,6-dialkyl derivatives with alkyl radicals generated from RCO2H (R = Me, Et, Pr, CHMe2, Bu). In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Quality Control of 2-Isopropylpyridine).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of 2-Isopropylpyridine