Chemistry of 3-hydroxypyridine. Part 1. Bromination and iodination of 3-hydroxypyridine was written by Koch, Volker;Schnatterer, Stefan. And the article was included in Synthesis in 1990.Synthetic Route of C5H3Br2NO This article mentions the following:
Bromination of 3-hydroxypyridine (I) with Br2 in aqueous NaOH gave 2-bromo, 2,6-dibromo, and 2,4-dibromo derivatives Iodination of I in aqueous Na2CO3 gave 2-iodo, 2,6-diiodo, and 2,4,6-triiodo derivatives Similarly, iodination of 2-bromo-3-hydroxypyridine gave 2-bromo-6-iodo- and 2-bromo-4,6-diiodo-3-hydroxypyridine. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Synthetic Route of C5H3Br2NO).
2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C5H3Br2NO