A directing group-assisted ruthenium-catalyzed approach to access meta-nitrated phenols was written by Sasmal, Sheuli;Sinha, Soumya Kumar;Lahiri, Goutam Kumar;Maiti, Debabrata. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Synthetic Route of C11H9NO This article mentions the following:
Meta-Selective C-H nitration of phenol derivatives RC6H4OR1 (R = H, 4-Me, 2-MeO, 4-Ph, etc.; R1 = pyridin-2-yl, 5-methylpyridin-2-yl, pyrimidin-2-yl) was developed using a Ru-catalyzed σ-activation strategy. Cu(NO3)2.3H2O was employed as the nitrating source, whereas Ru2(CO)12 was found to be the most suitable metal catalyst for the protocol. Mechanistic studies suggested involvement of an ortho-CAr-H metal intermediate, which promoted meta-electrophilic aromatic substitution and silver-assisted free-radical pathway. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Synthetic Route of C11H9NO).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Synthetic Route of C11H9NO