The hypoglycemic effect of (7R*,9aS*)-7-phenyl-octahydroquinolizin-2-one in mice was written by Kubo, Hajime;Kobayashi, Junji;Higashiyama, Kimio;Kamei, Junzo;Fujii, Yuji;Ohmiya, Shigeru. And the article was included in Biological & Pharmaceutical Bulletin in 2000.Safety of 4-Methoxy-2-methylpyridine This article mentions the following:
(-)-Multiflorine, which was isolated from leguminous plants, produced a hypoglycemic effect when administered to mice with streptozotocin-induced diabetes. (-)-Multiflorine has an enaminone type conjugation on the A-ring, which is unusual in lupine alkaloids. Proceeding on the assumption that the A-B ring is responsible for the activity, several compounds bearing quinolizidin-2-one were synthesized and their hypoglycemic effects were examined The hypoglycemic effect of (7R*,9aS*)-7-phenyl-octahydroquinolizin-2-one was approx. 4 times stronger than that of (-)-multiflorine measured by oral glucose tolerance test in normal mice. This result indicates that compounds possessing the quinolizidin-2-one ring system as the basic structure may be possible lead compounds for a new type of diabetes drug. In the experiment, the researchers used many compounds, for example, 4-Methoxy-2-methylpyridine (cas: 24103-75-1Safety of 4-Methoxy-2-methylpyridine).
4-Methoxy-2-methylpyridine (cas: 24103-75-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 4-Methoxy-2-methylpyridine