Improved synthesis of 4-substituted pyridines from nitriles was written by Chelucci, Giorgio;Giacomelli, Giampaolo;Scano, Gianfranco. And the article was included in Gazzetta Chimica Italiana in 1991.Application In Synthesis of 4-Hexylpyridine This article mentions the following:
4-Substituted pyridines I ( R = n-hexyl, iso-Bu, sec-Bu, Ph) were prepared by a 4-step sequence in 23-27% overall yield starting from RCH2CN. The synthesis involves alkylation of RCH2CN with BrCH2CH(OEt)2, then with 2-iodomethyl-1,3-dioxolane, removal of the CN group and reaction of the glutaraldehyde acetals II, thus obtained, with NH2OH.HCl in AcOH to give I. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Application In Synthesis of 4-Hexylpyridine).
4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 4-Hexylpyridine