Regioselective organometallic synthesis of pyridines, 4-picolines, and 3,5-lutidines substituted in the 2-position by an unsaturated and/or functional group was written by Al-Arnaout, A.;Courtois, G.;Miginiac, L.. And the article was included in Journal of Organometallic Chemistry in 1987.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:
[(Alkoxycarbonyl)oxy]pyridinium chlorides I (R1 = Et, CH2CHMe2; R2 = H, Me; R3 = H, Me) were treated with 2-alkenylzinc bromides to give pyridines II (R4 = 2-alkenyl). Similarly, II [R4 = C椤氬挵(CH:CH)nCH2OR5 (n = 0, 1; R5 = H, Me)] were prepared from I and R5OCH2(CH:CH)nC椤氬挵MgBr. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 3,5-Dimethylpyridine 1-oxide