Design, Synthesis and Anticancer Activity of Aza Heterocycles Containing Gallate Moiety (Part III) was written by El-Ebiary, N. M.;Swellem, R. H.;Nawwar, G. A. M.. And the article was included in Pharmaceutical Chemistry Journal in 2017.Related Products of 628-13-7 This article mentions the following:
Our previously reported compound, 3-(2-hydroxy-3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde, was allowed to react with acetophenone, Et cyanoacetate and/or malononitrile to give the corresponding compounds, e.g. I, which were treated with thiourea afforded thiopyrimidine derivatives The coupling of 3a and 3b with 2′,3′,4′,6′-tetra-O-acetyl-_-D-glucopyranosyl bromide (4) afforded compounds 5a and 5b, resp. Reaction of I with acetophenone yielded pyridone derivative II, which was fused in pyridine hydrochloride to give demethylated product. The coupling of II with some cyclic and acyclic halosugars afforded various N-glycoside derivatives New compounds were tested for their antitumor activity on MCF-7 human breast adenocarcinoma cell line and HepG2 liver carcinoma cell line. Almost all tested compounds exhibited antitumor activity, especially II, which displayed the most potent inhibitory activity with IC50 = 2.97 and 2.67 g/mL against MCF-7 and HepG2 cell lines, resp. Compound 6 was tested for its acute toxicity (LD) and found to have very low toxicity based on LD50 values (no label > 600 < 2000 mg/kg) as recommended by the Organization for Economic Co-operation and Development. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Related Products of 628-13-7).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 628-13-7