Effect of Activation Methods of Molecular Sieves on Ketimine Synthesis was written by Yasukawa, Tomohiro;Nakajima, Hanako;Masuda, Ryusuke;Yamashita, Yasuhiro;Kobayashi, Shu. And the article was included in Journal of Organic Chemistry.Formula: C12H9NO This article mentions the following:
Although the use of mol. sieves for imine synthesis is a common protocol, there have been no comprehensive studies on heat-drying methods, and this can be crucial for reproducibility. It was found that mol. sieve 5A dried at 160 鎺矯 for 5 h under vacuum efficiently promoted the condensation of various ketones RC(O)R1 (R = n-Pr, Ph, 4-flurophenyl, etc.; R1 = Ph, Me, pyridin-2-yl, etc.) and amines R2NH2 (R2 = Ph, 4-chlorophenyl, cyclohexyl, etc.) to afford even relatively bulky ketimines RC(R1)=NR2. Several control experiments and analyses revealed that only a small amount of Bronsted acid sites was important for the activity, rather than dehydration ability. Other types of mol. sieves could be utilized for the reaction after treatment with water followed by heat drying. A continuous-flow acetalization reaction of alcs. using the activated mol. sieve 5A was also demonstrated. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Formula: C12H9NO).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H9NO