The C-H activated controlled mono- and di-olefination of arenes in ionic liquids at room temperature was written by Du, Kaifeng;Yao, Tian. And the article was included in RSC Advances in 2020.Application of 4373-61-9 This article mentions the following:
The controlled mono and di-olefination of arenes was first realized at room temperature via the C-H bond activation in ionic liquids, probably due to the pos. effects of ionic liquids was reported. It was an energy-saving routes in industrial production without the need for heating equipment. Different catalysts were screened, and it was found that [Ru(p-cymene)Cl2]2 generated mono-olefinated products predominantly while [Cp*RhCl2]2 selectively gave di-olefinated products. These catalysts ([BMIM]NTf2 and [BMIM]PF6) as green and recyclable reaction media were highly efficient under mild conditions. This reaction process was avoid any volatile and environmentally toxic organic solvents, and was much safer without the need for pressure-tight equipment. A wide substrate scope with good yields and satisfactory selectivity was achieved. The reactions was scaled up to gram-scale. Furthermore, an expensive rhodium/ruthenium catalytic system was recycled for at least 6 times with consistently high catalytic activity, which was economical and environmental friendly from an industrial point of view. According to the mechanistic study, the C-H bond cleavage was probably achieved via the concerted metalation-deprotonation. This technique was applied in the synthesis of various valuable unsaturated aromatic compounds and showed a great potential for industrial production In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application of 4373-61-9).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 4373-61-9