Development of an Operationally Simple, Scalable, and HCN-Free Transfer Hydrocyanation Protocol Using an Air-Stable Nickel Precatalyst was written by Reisenbauer, Julia C.;Bhawal, Benjamin N.;Jelmini, Nicola;Morandi, Bill. And the article was included in Organic Process Research & Development in 2022.Product Details of 91-02-1 This article mentions the following:
Herein, HCN-free transfer hydrocyanation of alkenes and alkynes that employed com. available aliphatic nitriles R1CC(CN)R1 [R1 = Ph, 2-MeC6H4, 4-PhC6H4, etc.; R2 = H; R1R2 = (CH2)6] and alkenyl nitriles R1C=C(CN)R1 [R1 = nPr, nBu, SiMe3 R2 = nPr, nBu, Ph] as sacrificial HCN donors in combination with a catalytic amount of air-stable and inexpensive NiCl2 as a precatalyst and a cocatalytic Lewis acid was reported. The scalability and robustness of the catalytic process were demonstrated by the hydrocyanation of 浼?methylstyrene on a 100 mmol scale (11.4 g of product obtained) using 1 mol % of the Ni catalyst. In addition, the feasibility of the dehydrocyanation protocol using the air-stable Ni(II) precatalyst and norbornadiene as a sacrificial acceptor was showcased by the selective conversion of an aliphatic nitrile into the corresponding alkene. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Product Details of 91-02-1).
Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 91-02-1