Nickel-Catalyzed Cross-Coupling of Aryl 2-Pyridyl Ethers with Organozinc Reagents: Removal of the Directing Group via Cleavage of the Carbon-Oxygen Bonds was written by Dai, Wei-Can;Yang, Bo;Xu, Shi-He;Wang, Zhong-Xia. And the article was included in Journal of Organic Chemistry in 2021.Related Products of 4783-68-0 This article mentions the following:
Reaction of aryl 2-pyridyl ethers with arylzinc reagents under catalysis of NiCl2(PCy3)2 afforded aryl-aryl cross-coupling products Ar2Ar1 [R = Ph, 4-FC6H4, 4-MeOC6H4, etc.; Ar1 = 4-N(Me)2C6H4, 4-MeC6H4, 4-MeOC6H4, etc.] via selective cleavage of CAr-OPy bonds. The reaction features a wide substrate range and good compatibility of functional groups. ็?H-free alkylzinc reagents were also applicable as the nucleophiles in the transformation, whereas ็?H-containing alkylzinc reagents led to a mixture of cross-coupling and hydrogenation products Ar2Ar1. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Related Products of 4783-68-0).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 4783-68-0