Kinetics and mechanism of the electrophilic substitution of heteroaromatic compounds. XL. Standardization of aromatic and heteroaromatic nitration rates was written by Katritzky, Alan R.;Terem, Bulent;Scriven, Eric V.;Clementi, Sergio;Tarhan, H. Okan. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1975.COA of Formula: C7H9NO This article mentions the following:
Methods for extrapolating rates for nitrations in aqueous H2SO4 to different temperatures and acidities are discussed. The determination of standard (25鎺? H0 -6.6) nitration rates (k20) from exptl. measured rates required 4 consecutive steps: determination of the observed rate (k2) at the individual acidity and temperature, involving knowledge of the acidity function followed and its variation with temperature, determination of k2(T) at H0 -6.6, involving construction of the rate profile and its extrapolation to the proper acidity, determination of k2 (25鎺? at the standard acidity, involving evaluation or estimation of the thermodn. parameters at that acidity, and determination of k20, involving correction for minority species reaction, which requires knowledge of the pKa of the substrate at the standard temperature The procedure was applied to literature data for 131 nitration rates. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8COA of Formula: C7H9NO).
3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.COA of Formula: C7H9NO