Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic was written by Miller, William H.;Alberts, Doreen P.;Bhatnagar, Pradip K.;Bondinell, William E.;Callahan, James F.;Calvo, Raul R.;Cousins, Russell D.;Erhard, Karl F.;Heerding, Dirk A.;Keenan, Richard M.;Kwon, Chet;Manley, Peter J.;Newlander, Kenneth A.;Ross, Stephen T.;Samanen, James M.;Uzinskas, Irene N.;Venslavsky, Joseph W.;Yuan, Catherine C.-K.;Haltiwanger, R. Curtis;Gowen, Maxine;Hwang, Shing-Mei;James, Ian E.;Lark, Michael W.;Rieman, David J.;Stroup, George B.;Azzarano, Leonard M.;Salyers, Kevin L.;Smith, Brian R.;Ward, Keith W.;Johanson, Kyung O.;Huffman, William F.. And the article was included in Journal of Medicinal Chemistry in 2000.Application of 205676-84-2 This article mentions the following:
A new series of small mol. RGD mimetics that are highly potent, orally active 浼獀灏? antagonists is described. Selected members of this series are potent inhibitors of bone resorption in vitro and in vivo and have activity in an animal model of osteoporosis. In the experiment, the researchers used many compounds, for example, tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2Application of 205676-84-2).
tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 205676-84-2