Synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel FMS inhibitors was written by Kim, Yu-Yon;Choi, Jaeyul;Choi, Kyungjin;Park, Changhee;Kim, Young Hoon;Suh, Kwee Hyun;Ham, Young Jin;Jang, Sun Young;Lee, Kyu-Hang;Hwang, Kwang Woo. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Application of 315180-16-6 This article mentions the following:
Colony stimulating factor-1 receptor (CSF-1R or FMS) and it ligand, CSF-1, signaling regulates the differentiation and function of tumor-associated macrophages (TAMs) that play an important role in tumor progression. Derivatives of thieno[3,2-d]pyrimidine were synthesized and evaluated as kinase inhibitors of FMS. The most representative compound I showed strong activity (IC50 = 2 nM) against FMS kinase and served as candidate for proof of concept. Anti-tumor activity alone and/or in combination with paclitaxel was examined via a tumor cell growth inhibition assay and via an in vitro tumor invasion assay using human breast adenocarcinoma cells. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-6-fluoropyridine (cas: 315180-16-6Application of 315180-16-6).
2-(Chloromethyl)-6-fluoropyridine (cas: 315180-16-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application of 315180-16-6