Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 211915-84-3, Name is Ethyl 3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate, molecular formula is C27H26N6O3. In an article, author is Bhalekar, Sujit B.,once mentioned of 211915-84-3, Recommanded Product: 211915-84-3.
Synthesis, Biological and Molecular Docking Study of Benzimidazole-Clubbed Tetrahydrothieno [3, 2-c] Pyridine as Platelet Inhibitors
Two novel series of tetrahydrothienopyridine clubbed benzimidazole hybrids were synthesized, characterized by spectral studies H-1 NMR, IR and mass analysis. Synthesized analogs were screened for in vitro antiplatelet activity. In addition, active analogs were further subjected in presence of proton pump inhibitors against standard prasugrel and aspirin to check minimization in antiplatelet activity. Active analogs 1-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethan-1-one (11) and (2-(1-(2-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)(3,4,5-trichlorophenyl)methanone (25) were significantly found more active than the standards in the presence of proton pump inhibitors. The structure and antiplatelet activity relationship was supported by molecular docking studies of active analogs to know how effectively, activity influenced by the merger of proton pump inhibitor precursor benzimidazole. The above studies successfully revealed that the synthesized analogs may found more active with further amendments via pharmacological point of view.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem