Synthesis and characterization of N-hydroxy-7-(3-substituted ureido)-4-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)-1,8-naphthyridine-2-carboxamides: a novel class of potential antibacterial, antifungal and anthelmintic agents was written by Prasad, V. Kamala;Sanjeeva, P.;Manjunath, G.;Rao, B. Subba;Ramana, P. Venkata. And the article was included in Heterocyclic Letters in 2022.Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide This article mentions the following:
N-hydroxy-7-(3-substituted ureido)-4-(4-((4-(morpholinomethyl)phenyl)ethynyl) phenyl)-1,8-naphthyridine-2-carboxamides I [R = Et, i-Pr, Ph, etc.; R1 = NHOH] were synthesized by treating Me 7-(3-substituted ureido)-4-(4-((4-(morpholinomethyl)phenyl)ethynyl) phenyl)-1,8-naphthyridine-2-carboxylate I [R1 = OMe] with hydroxylamine in ethanol/THF. These newly synthesized 1,8-naphthyridine derivatives I were screened for their antibacterial, antifungal and anthelmintic activities against the resp. strains. The results showed that introduction of electron donating groups in the ureido moiety results in a significant decrease of antimicrobial activity and an increase in anthelmintic activity. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide).
N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide