Synthesis of 2-chloro-3-amino-4-methylpyridine oxychloride cement was written by Xiao, Qing;Liu, Anchang;Tan, Zhenyou;Liu, Fang. And the article was included in Wuhan Gongcheng Daxue Xuebao in 2008.Synthetic Route of C7H5ClN2 This article mentions the following:
2-Chloro-3-amino-4-methylpyridine was synthesized with 4,4-dimethoxy-2-butanone and malononitrile as raw material by Knoevenagel condensation, cyclization, chlorination, hydrolysis and Hoffman reaction, and the overall yield was 57.3% (mol). The objective compound was characterized by IR and 1H NMR. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2Synthetic Route of C7H5ClN2).
2-Chloro-4-methylpyridine-3-carbonitrile (cas: 65169-38-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C7H5ClN2