An efficient synthesis of highly functionalized chiral lactams was written by Ornelas, Martha A.;Gonzalez, Javier;Sach, Neal W.;Richardson, Paul F.;Bunker, Kevin D.;Linton, Angelica;Kephart, Susan E.;Pairish, Mason;Guo, Chuangxing. And the article was included in Tetrahedron Letters in 2011.HPLC of Formula: 3939-12-6 This article mentions the following:
A new method was developed to synthesize highly functionalized lactams, e.g., I, via a one pot reductive amination/lactam formation reaction. This methodol. is amenable for parallel synthesis and was used to prepare a large number of lactam analogs in a library format with good ee (de) retention. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6HPLC of Formula: 3939-12-6).
6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.HPLC of Formula: 3939-12-6