Synthesis of G protein-coupled receptor 119 agonist MBX-2982 was written by Ding, Lu;Luo, Tang;Song, Kai-zhen;Gong, Ping;Han, Jing. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2012.Synthetic Route of C11H20N2O2S This article mentions the following:
Type 2 diabetes is emerging as a disease of staggering proportions in twenty-first century. MBX-2982, discovered by Metabolex company, is a potential oral first-in-class treatment for type 2 diabetes that targets G protein-coupled receptor 119. According to the synthetic methods of MBX-2982 in literature, a new route was developed. The target compound was prepared from 4-cyanopiperidine-1-carboxylic tert-Bu ester via five steps including sulfidation, condensation, etherification, deprotection and substitution. The overall yield was 42.8% (based on 4-cyanopiperidine-1-carboxylic tert-Bu ester), which was 12% higher than that reported in the literature. The synthetic methods of intermediate 2, 6 and MBX-2982 were improved. The final structure and some intermediates were confirmed by 1H-NMR and MS. Compared with the synthetic process in literature, this route has an economic advantage in view of application to in-depth study. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Synthetic Route of C11H20N2O2S).
tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Synthetic Route of C11H20N2O2S