Chain-walking cycloisomerization of 1,n-dienes catalyzed by pyridine-oxazoline palladium catalysts and its application to asymmetric synthesis was written by Hamasaki, Taro;Kakiuchi, Fumitoshi;Kochi, Takuya. And the article was included in Chemistry Letters in 2016.Quality Control of (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole This article mentions the following:
Palladium catalysts possessing pyridine-oxazoline ligands, e.g., I, were found to catalyze the chain-walking cycloisomerization of 1,n-dienes, e.g., II, to form five-membered rings and were particularly effective for the reaction of 1,14-dienes, e.g., III. Asym. synthesis of cyclopentane derivatives was also achieved for the reaction of 1,n-dienes using chiral pyridine-oxazoline ligands. In the experiment, the researchers used many compounds, for example, (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1257527-14-2Quality Control of (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole).
(S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1257527-14-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole