Copper-catalyzed cyanation of heterocycle C-H bonds with ethyl(ethoxymethylene)cyanoacetate as a cyanating agent and its mechanism was written by Li, Ze-lin;Sun, Kang-kang;Cai, Chun. And the article was included in Organic Chemistry Frontiers in 2018.Application of 1620-76-4 This article mentions the following:
A method for synthesis of benzothiazole-2-carbonitriles such as I [R = H, 5-Cl, 6-Br, etc.; X = O, S], indole-3-carbonitriles II [R1 = H, 6-MeO, 6-Cl; R2 = H, Me; R3 = H, Me] and pyridine-2-carbonitriles III [R4 = H, 6-Me, 3-Br, etc.] was developed via copper-catalyzed cyanation of benzothiazoles/indoles/pyridines with ethyl(ethoxymethylene)cyanoacetate as a nontoxic and easily available cyanating agent. This transformation proceeded smoothly in the presence of di-tert-Bu peroxide (DTBP) with a wide substrate scope under ligand-free conditions. Mechanistic details were also described. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Application of 1620-76-4).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application of 1620-76-4