Novel Thiazole Derivatives as Inhibitors of Superoxide Production by Human Neutrophils: Synthesis and Structure-Activity Relationships was written by Chihiro, Masatoshi;Nagamoto, Hisashi;Takemura, Isao;Kitano, Kazuyoshi;Komatsu, Hajime;Sekiguchi, Kazuo;Tabusa, Fujio;Mori, Toyoki;Tominaga, Michiaki;Yabuuchi, Youichi. And the article was included in Journal of Medicinal Chemistry in 1995.Name: 6-Acetylpicolinic acid This article mentions the following:
Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated for inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3,4-diethoxyphenyl)thiazol-4-yl]pyridine-2-carboxylic acid (OPC-6535) was selected as one of the most promising compounds In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Name: 6-Acetylpicolinic acid).
6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Name: 6-Acetylpicolinic acid