Manganese-Catalyzed Kumada Cross-Coupling Reactions of Aliphatic Grignard Reagents with N-Heterocyclic Chlorides was written by Petel, Brittney E.;Purak, Merjema;Matson, Ellen M.. And the article was included in Synlett in 2018.Recommanded Product: 644-98-4 This article mentions the following:
The use of manganese(II) chloride for the catalytic generation of C(sp2)-C(sp3) bonds via Kumada cross-coupling is reported. Rapid and selective formation of 2-alkylated N-heterocyclic complexes was observed in high yields with use of 3 mol% MnCl2THF1.6and under ambient reaction conditions (21 鎺矯, 15 min to 20 h). Manganese-catalyzed cross-coupling is tolerant toward both electron-donating and electron-withdrawing functional groups in the 5-position of the pyridine ring, with the latter resulting in an increased reaction rate and a decrease in the amount of nucleophile required. The use of this biol. and environmentally benign metal salt as a catalyst for C-C bond formation highlights its potential as a catalyst for the late-stage functionalization of pharmaceutically active N-heterocyclic mols. (e.g., pyridine, pyrazine). In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Recommanded Product: 644-98-4).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 644-98-4