Relation of chemical constitution of some N-heterocyclic compounds to toxicity as fumigants was written by King, H. L.;Frear, D. E. H.. And the article was included in Journal of Economic Entomology in 1944.Product Details of 27876-24-0 This article mentions the following:
The following compounds were tested as fumigants in the laboratory against the confused flour beetle (Tribolium confusum): pyridine and these pyridine derivs: 2-Me-, 2-Et-, 2-Pr-, 2-iso-Pr-, 2-Bu-, 2-Am-, 2-hexyl- and isomers, 2-heptyl-, 2-octyl-, 2-(1-ethylhexyl)-, 2-(2-methyloctyl)-, 2-(1-amylhexyl)-, other 2-hendecyl isomers, 3-Me-, 4-Et-, 4-Pr-, 4-iso-Pr-, 4-Bu-, 4-Am-, 4-(3-pentyl)-, 4-hexyl- and isomers, 2,4-di-Me, 2,5-di-Me, 2,6-di-Me, 2-Et-6-Me-, 2-Bu-6-Me-, 2-Am-6-Me-, 2-hexyl-6-Me-, and 2-(hydroxyethyl)-. 2-Hexylpiperidine, 4-amylpiperidine and quinoline were included. The non-N compounds tested were CS2, Me acetate, Et acetate, bis-2-chloroethyl ether, ethylene dichloride and CCl4. Some of these compounds were also tested against the large milkweed bug (Oncopeltus fasciatus) and the red spider (Tetranychus telarius). Results: A pronounced peak of toxicity occurred in the 2-alkylpyridine series at the Pr or Bu derivatives Alkylpyridines with side chains in the 4-position were more toxic than 2-substituted isomers; compounds with normal side chains were usually more toxic than branched-chain isomers. The 2-alkylpiperidines tested were more toxic than the 2-alkylpyridines. The relative toxicities of the compounds tested on the red spider showed a strong correlation with their action on the 2 species of insects used in this investigation. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Product Details of 27876-24-0).
4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Product Details of 27876-24-0