2-Chloro-5-fluoro-3-nitropyridine (cas: 136888-21-6) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 136888-21-6
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme was written by Hamilton, Matthew M.;Mseeh, Faika;McAfoos, Timothy J.;Leonard, Paul G.;Reyna, Naphtali J.;Harris, Angela L.;Xu, Alan;Han, Michelle;Soth, Michael J.;Czako, Barbara;Theroff, Jay P.;Mandal, Pijus K.;Burke, Jason P.;Virgin-Downey, Brett;Petrocchi, Alessia;Pfaffinger, Dana;Rogers, Norma E.;Parker, Connor A.;Yu, Simon S.;Jiang, Yongying;Krapp, Stephan;Lammens, Alfred;Trevitt, Graham;Tremblay, Martin R.;Mikule, Keith;Wilcoxen, Keith;Cross, Jason B.;Jones, Philip;Marszalek, Joseph R.;Lewis, Richard T.. And the article was included in Journal of Medicinal Chemistry in 2021.Recommanded Product: 136888-21-6 This article mentions the following:
Indoleamine 2,3-dioxygenase 1 (IDO1), a heme-containing enzyme that mediates the rate-limiting step in the metabolism of L-tryptophan to kynurenine, has been widely explored as a potential immunotherapeutic target in oncol. The authors have developed a class of inhibitors with a conformationally constrained bicyclo[3.1.0]hexane core. These potently inhibited IDO1 in a cellular context by binding to the apoenzyme, as elucidated by biochem. characterization and X-ray crystallog. A SKOV3 tumor model was instrumental in differentiating compounds, leading to the identification of I (IACS-9779) and II (IACS-70465). IACS-70465 has excellent cellular potency, a robust pharmacodynamic response, and in a human whole blood assay was more potent than linrodostat (BMS-986205). IACS-9779 with a predicted human efficacious once-daily dose below 1 mg/kg to sustain >90% inhibition of IDO1 displayed an acceptable safety margin in rodent toxicol. and dog cardiovascular studies to support advancement into preclin. safety evaluation for human development. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-fluoro-3-nitropyridine (cas: 136888-21-6Recommanded Product: 136888-21-6).
2-Chloro-5-fluoro-3-nitropyridine (cas: 136888-21-6) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 136888-21-6
Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem