Molecular Engineering and Design of Semiconducting Polymer Dots with Narrow-Band, Near-Infrared Emission for in Vivo Biological Imaging was written by Ke, Chi-Shiang;Fang, Chia-Chia;Yan, Jia-Ying;Tseng, Po-Jung;Pyle, Joseph R.;Chen, Chuan-Pin;Lin, Shu-Yi;Chen, Jixin;Zhang, Xuanjun;Chan, Yang-Hsiang. And the article was included in ACS Nano in 2017.Synthetic Route of C5H6ClN This article mentions the following:
This article describes the design and synthesis of donor-bridge-acceptor-based semiconducting polymer dots (Pdots) that exhibit narrow-band emissions, ultrahigh brightness, and large Stokes shifts in the near-IR (NIR) region. The authors systematically studied the effect of 闂?bridges on the fluorescence quantum yields of the donor-bridge-acceptor-based Pdots. The Pdots could be excited by a 488 or 532 nm laser and have a high fluorescence quantum yield of 33% with a Stokes shift of >200 nm. The emission full width at half-maximum of the Pdots can be as narrow as 29 nm, 闂?.5 times narrower than that of inorganic quantum dots at the same emission wavelength region. The average per-particle brightness of the Pdots is at least 3 times larger than that of the com. available quantum dots. The excellent biocompatibility of these Pdots was demonstrated in vivo, and their specific cellular labeling capability was also approved by different cell lines. By taking advantage of the durable brightness and remarkable stability of these NIR fluorescent Pdots, the authors performed in vivo microangiog. imaging on living zebrafish embryos and long-term tumor monitoring on mice. The authors anticipate these donor-bridge-acceptor-based NIR-fluorescent Pdots with narrow-band emissions to find broad use in a variety of multiplexed biol. applications. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Synthetic Route of C5H6ClN).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C闂備胶鍋ㄩ崕鎻掝嚕?in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C5H6ClN