C-H Silylation of 2-Arylpyridine Derivatives by Using Iridium Catalyst and Phosphine-Borane Ligand was written by Anoyama, Keita;Onodera, Gen;Fukuda, Tsutomu;Kimura, Masanari. And the article was included in Advanced Synthesis & Catalysis in 2022.HPLC of Formula: 4373-61-9 This article mentions the following:
Iridium-catalyzed ortho-C-H silylation of 2-arylpyridine derivative with hydrosilane by using phosphine-borane ligands has been developed. A variety of 2-arylpyridines could be used for this reaction to give mono- and disilylated products in 81-99% yields. In this reaction, the length of linkage between phosphorus and boron plays an important role for the reaction to proceed. We consider that the nitrogen in 2-arylpyridine coordinates to Lewis acidic boron in the ligand and thus the iridium is led to an ortho-C-H bond to cleave it. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9HPLC of Formula: 4373-61-9).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 4373-61-9