In an article, author is Stiboller, Michael, once mentioned the application of 108-75-8, Computed Properties of C8H11N, Name is 2,4,6-Trimethylpyridine, molecular formula is C8H11N, molecular weight is 121.1796, MDL number is MFCD00006338, category is pyridine-derivatives. Now introduce a scientific discovery about this category.
Lipid-soluble arsenic species identified in the brain of the marine fish skipjack tuna (Katsuwonus pelamis) using a sequential extraction and HPLC/mass spectrometry
Lipid-soluble arsenicals, so called arsenolipids, occur in appreciable quantities in various marine organisms including fish. In this study, arsenolipids as well water-soluble arsenic species were investigated in brain (9.1-17.4 mg As per kg; dry mass) and muscle (4.0-5.8 mg As per kg; dry mass) tissues in five specimens of the marine fish skipjack tuna (Katsuwonus pelamis). For this purpose, we developed a sequential extraction method whereby the freeze-dried tissue was first treated with pyridine (organic extract) followed by aqueous ammonium bicarbonate (water extract) to extract arsenolipids and water-soluble species, respectively. When the method was applied to the tuna tissues, the arsenic distribution for brain was 55% (organic extract), 30% (water extract) and 15% (pellet), whereas for muscle tissue the corresponding values were 20%, 55%, and 25%. Arsenic species in water and organic extracts of muscle and brain tissues were investigated by HPLC/mass spectrometry. For both tissues, the water extracts contained arsenobetaine as the major arsenic species together with small amounts of dimethylarsinate and trimethylarsine oxide; trace amounts of dimethylarsinoyl propionic acid were found only in brain tissues. Arsenic-containing hydrocarbons (AsHCs), were the major arsenolipids in both tuna brain and muscle. The arsenolipid content in brain ranged from 3.8-5.9 mg As per kg, whereas it was substantially lower in muscle (0.3-0.8 mg As per kg) reflecting arsenolipids’ potential to cross the blood brain barrier and accumulate in the fish brain.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem