In an article, author is Zhang, Qian, once mentioned the application of 74976-31-1, Name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine, molecular formula is C7H5ClN2, molecular weight is 152.58, MDL number is MFCD08690133, category is pyridine-derivatives. Now introduce a scientific discovery about this category, SDS of cas: 74976-31-1.
Radical Reactivity, Catalysis, and Reaction Mechanism of Arylcopper(II) Compounds: The Missing Link in Organocopper Chemistry
Organocopper(I) compounds are recognized as carbon nucleophiles, while organocopper(III) complexes are involved in copper catalysis as intermediates to undergo a cross-coupling reaction with various anionic nucleophiles. In contrast to the chemistry of organocopper(I) and (III) compounds, organocopper(II) chemistry is virtually a missing link in integral organocopper chemistry because structurally well-defined organocopper(II) compounds have barely been isolated or studied. We report in this Article an investigation of the radical reactions of stable and structurally well-defined arylcopper(II) compounds, obtained readily from the arene C-H bond reaction of macrocyclic azacalix[1]arene[3]pyridines and Cu(ClO4)(2). We have found that arylcopper(II) compounds acted as essentially radical species to undergo an efficient three-component reaction with radical initiators 2,2′-azobis(isobutyronitrile) (AIBN) or 2,2′-azobis(2,4-dimethylvaleronitrile) (ABVN) and alpha,beta-unsaturated compounds CH2=CHX (X = CO2CH3, CN, CONH2, COCH3, and SO2Ph) to afford polyfunctionalized products. Combined experimental and theoretical studies revealed that radicals couple directly with the C-aryl atom of arylcopper(II) compounds to form C-alkyl-C-aryl bonds through a Cu(II)/Cu(I) mechanism. Comprehension of the formation and radical reactivity of arylcopper(II) compounds has allowed the development of a copper-catalyzed three-component radical reaction for arene C-H bond functionalization.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 74976-31-1, SDS of cas: 74976-31-1.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem