Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Hassan, Mohamed, I, once mentioned the application of 500-22-1, Name is 3-Pyridinecarboxaldehyde, molecular formula is C6H5NO, molecular weight is 107.11, MDL number is MFCD00006382, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Product Details of 500-22-1.
Synthesis, Characterization and in vitro Antibacterial Evaluation of New Oxindoles and Spiro-Oxindoles Derivatives
ARYLIDENES oxindole 3 and 5 were synthesized via the reactions of isatin 1 with malononitrile dimmer 2 and 5-amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile 4. Compound 3 react by Michael addition with malononitrile, ethyl 2-cyanoacetate and acetyl acetone to give 6′-amino-2′-(dicyanomethylene)-2-oxo-2′,3′-dihydro-1’H-spiro[indoline-3,4′-pyridine]-3′,5′-dicarbonitrile 6a, 2′-(dicyanomethylene) 2,6′-dioxospiro[indoline-3,4′-piperidine]-3′,5′-dicarbonitrile 6b and 2-(5′-acetyl-3′-cyano-6′-methyl-2-oxo-1’H-spiro[indoline-3,4′-pyridin]-2′(3’H) ylidene) malononitrile 7, respectively. compound 3 also, reacted with dimethylformamide dimethyl acetal to give N,N-dimethyl-N’-(1,1,3-tricyano-3-((Z)-2-oxoindolin-3-ylidene)prop-1-en-2-yl)formimidamide 7 which cyclized by ammonium acetate to give 4-amino-6-(cyano(2-oxoindolin-3-ylidene)methyl)pyrimidine-5-carbonitrile 8. Compound 5 reacted with dimedone 10 and acetyl acetone to give 3-(cyano(2-oxoindolin-3-ylidene)methyl)-5-((5,5-dimethyl-3-oxocyclohex-1-en-1-yl)amino)-1H-pyrazole-4-carbonitrile 11 and 2-(cyano(2-oxoindolin-3-ylidene)methyl)-5,7dimethylpyrazolo[1,5-a] pyrimidine-3-carbonitrile 12. Moreover, compound 3 and 5 reacted with hydrazine to give 3,3′-(hydrazine-1,2-diylidene)bis(indolin-2-one) 15. The antibacterial activities of the synthesized compounds were evaluated.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem