Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 24484-93-3, Name is Methyl 4-chloropicolinate, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Alzahrani, Hayat E., COA of Formula: C7H6ClNO2.
Selective cyclization of S-substituted pyrimidinethione: Synthesis and antimicrobial evaluation of novel polysubstituted thiazolopyrimidine and thiazolodipyrimidine derivatives
The synthetic strategy is based on alkylation of 4-aryl-N-(4-chlorophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide derivatives IV a-g, with some alkyl halides and alpha-haloketones, namely, methyl iodide, chloroacetonitrile, and phenacyl bromide to give the corresponding S-substituted derivatives Va-c. Treatment of IVa-c with ethyl bromoacetate in ethanol under reflux in the presence of potassium hydroxide solution led to the formation of N-(4-chlorophenyl)-7-methyl-3-oxo-5-(aryl)-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxamide derivative VIII a-c in a single-step synthesis. On the other hand, compound IVa reacted with alpha-halo carbonitriles, namely, chloro acetonitrile, and monobromo malononitrile, to produce directly thiazolo[3,2-a]pyrimidine derivatives Xa and Xb, respectively, Compound Xb also reacted with each of formic acid, formamide, and ammonium thiocyanate to form thiazolodipyrimidine derivatives XI-XIII, respectively. Compound VIIIa-c coupled with arenediazonium salts in pyridine to give the corresponding 2-arylhydrazo derivatives XVIa-e. Compounds IV a-g and VIIIa-c were resynthesized under microwave irradiation. Some of the newly synthesized compounds were tested for their antimicrobial activities.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 24484-93-3, in my other articles. COA of Formula: C7H6ClNO2.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem