The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one, 545445-44-1, Name is 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one, SMILES is O=C1C(N2CCOCC2)=CCCN1C3=CC=C(N4C(CCCC4)=O)C=C3, in an article , author is Gangireddy, Madhusudhana Reddy, once mentioned of 545445-44-1.
Design and Synthesis of Piperazine-Linked Imidazo[1,2-a]pyridine Derivatives as Potent Anticancer Agents
Designed, synthesized a series of novel imidazo[1,2-a]pyridine derivatives and evaluated for their in vitro cytotoxicity. Fluorine containing compounds, (2-fluorophenyl)(4-(2-(pyridin-2-yl)imidazo[1,2-a]pyridin-6-yl)piperazin-1-yl)methanone (7e),(4-(2-(pyridin-2-yl)imidazo[1,2-a]pyridin-6-yl)piperazin-1-yl)(2-(trifluoromethyl)phenyl)methanone (7 h) and (3-fluorophenyl) (4-(2-(pyridin-2-yl)imidazo[1,2-a]pyridin-6-yl)piperazin-1-yl)methanone (7i) were found to have an effective cytotoxic profile against HepG2, HeLa and MDA-MB-231. Compounds 7h (IC50 = 5.8 mu M) and 7i (IC50 = 3.5 mu M) were found potent when compared with control Paclitaxel (IC50 = 2.8 mu M), against HeLa. Compound 7h also found to be potent against HepG2 (IC50 = 2.0 mu M) and MDAMB-231(IC50 = 6.9 mu M) respectively, when compared with Paclitaxel (HepG2, IC50 = 0.56 mu M; MDAMB-231, IC50 = 1.9 mu M). Compound 7e also found to be potent against HepG2 (IC50 = 9.8 mu M) cell lines. Synthesized piperazine linked imidazo[1,2-a]pyridine derivatives (7i, IC50 = 3.5 mu M) and (7h, IC50 = 5.8 mu M) showed 1.74 fold, 1.12 fold increase in antiproliferative activity than reported homopiperazine linked imidazo [1,2-a]pyrimidine derivatives (4-Fluorophenyl)(4-(2-(4-fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl)-1,4-diazepan-1-yl)-methanone(10f, IC50 = 6.12 mu M) and (4-(2-(4-Fluorophenyl)imidazo[1,2-a]pyrimidin-7-yl)-1,4-diazepan-1-yl)(3-methoxyphenyl)methanone (12, IC50 = 6.54 mu M) against Hela cell lines. Molecular docking studies showed that designed compounds occupy at the active site of both colchicine and human estrogen receptor which demonstrated that the designed compounds were able to bind with multiple targets, the biological activity of these compounds hold promise to find application in considering for treatment protocol.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 545445-44-1, you can contact me at any time and look forward to more communication. Recommanded Product: 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem