In an article, author is Su, Peiling, once mentioned the application of 145100-51-2, COA of Formula: C7H3ClF6N2O4S2, Name is 2-[N,N-Bis(Trifluoromethylsulphonyl)amino]-5-chloropyridine, molecular formula is C7H3ClF6N2O4S2, molecular weight is 392.6831, MDL number is MFCD00191833, category is pyridine-derivatives. Now introduce a scientific discovery about this category.
Chemo-enzymatic synthesis of adenine substituted nicotinic acid adenine dinucleotide phosphate (NAADP) analogs
Nicotinamide adenine dinucleotide phosphate (NADP) is an indispensable metabolic co-substrate and nicotinic acid adenine dinucleotide phosphate (NAADP) is an important Ca2+ releasing intracellular second messenger. Exploration of the NADP and NAADP interactome often requires the synthesis of NADP derivatives substituted on the adenosine nucleoside. The introduction of the 2′-phosphate of NADP makes the synthesis of substituted NADP derivatives difficult. We have employed recombinant human NAD kinase expressed in E. roll as an enzymatic reagent to convert readily available synthetic NAD derivatives to NADP analogs, which were subsequently transformed into NAADP derivatives using enzyme catalyzed pyridine base exchange. 8-Ethynyl-NADP, 8-ethynyl-NAADP and 5-N-3-8-ethynyl-NAADP were synthesized starting from a protected 8-ethynyladenosine using a combination of chemical and enzymatic steps and the NAADP derivatives shown to be recognized by the sea urchin NAADP receptor at low concentration. Our methodology will enable researchers to produce mono- and bi-substituted NADP and NAADP analogs that can be applied in proteomic studies to identify NADP and NAADP binding proteins.
If you are interested in 145100-51-2, you can contact me at any time and look forward to more communication. COA of Formula: C7H3ClF6N2O4S2.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem