The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Formula: C17H21N3O, 61337-89-1, Name is 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol, SMILES is CN1CCN(C(C1)C1=CC=CC=C1)C1=C(CO)C=CC=N1, in an article , author is Pabst, Tyler P., once mentioned of 61337-89-1.
Mechanistic Origins of Regioselectivity in Cobalt-Catalyzed C(sp(2))-H Borylation of Benzoate Esters and Arylboronate Esters
Synthetic and mechanistic investigations into the C(sp(2))-H borylation of various electronically diverse arenes catalyzed by bis(phosphine)pyridine ( IPr PNP) cobalt complexes are reported. Borylation of various benzoate esters and arylboronate esters gave remarkably high selectivities for the position para to the functional group; in both cases, this regioselectivity was found to override the orthoto-fluorine regioselectivity, previously reported for ((PNP)-P-iPr)Co borylation catalysts, which arises from thermodynamic control of C(sp(2))-H oxidative addition. Mechanistic studies support pathways that result in para-to-ester and para-to-boronate ester selectivity by kinetic control of B-H and C(sp(2)-H) oxidative addition, respectively. Borylation of a particularly electron-deficient fluorinated arylboronate ester resulted in acceleration of C(sp(2))-H oxidative addition and concomitant inversion of regioselectivity, demonstrating that subtle changes in the relative rates of individual steps of the catalytic cycle can enable unique and switchable site selectivities.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 61337-89-1, you can contact me at any time and look forward to more communication. Formula: C17H21N3O.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem