Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Hasenbeck, Max, once mentioned the application of 120202-71-3, Name is (R)-Methyl 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate, molecular formula is C16H18ClNO6S2, molecular weight is 419.9, MDL number is MFCD17215518, category is pyridine-derivatives. Now introduce a scientific discovery about this category, COA of Formula: C16H18ClNO6S2.
Efficient Organocatalytic Dehydrogenation of Ammonia Borane
Dehydrogenation of ammonia borane by sterically encumbered pyridones as organocatalysts is reported. With 6-tert-butyl-2-thiopyridone as the catalyst, a turnover frequency (TOF) of 88 h(-1) was achieved. Experimental mechanistic investigations, substantiated by DLPNO-CCSD(T) computations, indicate a mechanistic scenario that commences with the protonation of a B-H bond by the mercaptopyridine form of the catalyst. The reactive intermediate formed by this initial protonation was observed by NMR spectroscopy and the molecular structure of a surrogate determined by SCXRD. An intramolecular proton transfer in this intermediate from the NH3 group to the pyridine ring with concomitant breaking of the S-B bond regenerates the thiopyridone and closes the catalytic cycle. This step can be described as an inorganic retro-ene reaction.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem