Chemistry, like all the natural sciences, SDS of cas: 1202-34-2, begins with the direct observation of nature¡ª in this case, of matter.1202-34-2, Name is Di(pyridin-2-yl)amine, SMILES is C1(NC2=NC=CC=C2)=NC=CC=C1, belongs to pyridine-derivatives compound. In a document, author is Haider, Ahmed, introduce the new discover.
Structure-Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors
The cannabinoid type 2 (CB2) receptor has emerged as a valuable target for therapy and imaging of immune mediated pathologies. With the aim to find a suitable radiofluorinated analogue of the previously reported CB2 positron emission tomography (PET) radioligand [C-11]RSR-056, 38 fluorinated derivatives were synthesized and tested by in vitro binding assays. With a K-i (hCB2) of 6 nM and a selectivity factor of nearly 700 over cannabinoid type 1 receptors, target compound 3 exhibited optimal in vitro properties and was selected for evaluation as a PET radioligand. [F-18]3 was obtained in an average radiochemical yield of 11 +/- 4% and molar activities between 33 and 114 GBq/mu mol. Specific binding of [F-18]3 to CB2 was demonstrated by in vitro autoradiography and in vivo PET experiments using the CB2 ligand GW-405 833. Metabolite analysis revealed only intact [F-18]3 in the rat brain. [18F]3 detected CB2 upregulation in human amyotrophic lateral sclerosis spinal cord tissue and may thus become a candidate for diagnostic use in humans.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 1202-34-2. SDS of cas: 1202-34-2.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem