Synthetic Route of 41468-25-1, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 41468-25-1, Name is (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate hydrate, SMILES is O=P(O)(OCC1=C(C=O)C(O)=C(C)N=C1)O.[H]O[H], belongs to pyridine-derivatives compound. In a article, author is Eli Alejandra, Garcimarrero-Espino, introduce new discover of the category.
Synthesis of new azaindeno-acetonitrile derivative with inotropic activity against heart failure model
Several steroid derivatives have prepared as inotropic drugs; however, there are few reports on azaindeno-steroid derivatives with inotropic activity. The objective of this investigation was to prepare some azaindeno-acetonitrile derivatives (compounds 3 to 7) to evaluate their biological activity on left ventricular pressure. The first step was achieved by preparation of azaindeno-steroid derivatives using reactions of etherification and addition. The second stage involves the evaluation of biological activity from azaindeno-steroidderivatives on left ventricular pressure in a heart failure model using either estrone or an enone-steroid derivative (compound 2) as controls. The results showed that only compound 6 increases left ventricular pressure compared with estrone, compounds 2-5 and 6. Inconclusion, the positive inotropic effect exerted by compound 6 depends on the functional groups involved in its chemical structure.
Synthetic Route of 41468-25-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 41468-25-1 is helpful to your research.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem