In an article, author is Alvarez-Miguel, Lucia, once mentioned the application of 628-13-7, SDS of cas: 628-13-7, Name is Pyridinehydrochloride, molecular formula is C5H6ClN, molecular weight is 115.56, MDL number is MFCD00012802, category is pyridine-derivatives. Now introduce a scientific discovery about this category.
Copper complexes for the promotion of iminopyridine ligands derived from beta-alanine and self-aldol additions: relaxivity and cytotoxic properties
In the study presented herein, we explore the ability of copper complexes with coordinated pyridine-2-carboxaldehyde (pyca) or 2-acetylpyridine (acepy) ligands to promote the addition of amines (Schiff condensation) and other nucleophiles such as alcohols (hemiacetal formation). Distinct reactivity patterns are observed: unlike pyca complexes, acepy copper complexes can promote self-aldol addition. The introduction of a flexible chain via Schiff condensation with beta-alanine allows the possibility of chelate ring ring-opening processes mediated by pH. Further derivatization of the complex [CuCl(py-2-C(H)?NCH2CH2COO)] is possible by replacing its chloride ligand with different pseudohalogens (N-3(-), NCO- and NCS-). In addition to the change in their magnetism, which correlates with their solid-state structures, more unexpected effects in their cytotoxicity and relaxitivities are observed, which determines their possibility to be used as MRI contrast agents. The replacement of a chloride by another pseudohalogen, although a simple strategy, can be used to critically change the cytotoxicity of the Schiff base copper(ii) complex and its selectivity towards specific cell lines.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem