Synthetic Route of 41468-25-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 41468-25-1, Name is (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate hydrate, SMILES is O=P(O)(OCC1=C(C=O)C(O)=C(C)N=C1)O.[H]O[H], belongs to pyridine-derivatives compound. In a article, author is Wang, Yanyan, introduce new discover of the category.
Synthesis of Anthranilic Diamide Derivatives Containing Moieties of Trifluoromethylpyridine and Hydrazone as Potential Anti-Viral Agents for Plants
A series of novel anthranilic diamide derivatives (5a-5ab) containing moieties of trifluoromethylpyridine and hydrazone was designed and synthesized. The synthesized compounds were evaluated in vivo for their activities against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV). Most of the synthesized compounds displayed good to excellent antiviral activities. The compounds 5i, 5k, 5s, 5w, 5x, and 5z had the curative activity over 65% against TMV at the concentration of 500 mu g/mL, which were significantly higher than those of ningnanmycin (55.0%) and ribavirin (37.9%). Notably, the curative activity of compound Si was up to 79.5%, with the EC50 value of 75.9 mu g/mL, whereas the EC50 value of ningnanmycin was 362.4 mu g/mL. The pot experiments also further demonstrated the significantly curative effect of Si. Meanwhile, compounds 5h, 5p and Sx displayed more protective activities on TMV than that of ningnanmycin. Moreover, compounds 5a, 5e, 5f, and 5i showed inactivation activity similar to ningnanmycin at 500 mu g/mL, and the EC50 value of Se (41.5 mu g/mL) was lower than ningnanmycin (50.0 mu g/mL). The findings of transmission electron microscopic (TEM) indicated that the synthesized compounds exhibited strong and significant binding affinity to TMV coat protein (CP) and could obstruct the self-assembly and increment of TMV particles. Microscale thermophoresis (MST) studies on TMV-CP and CMV CP revealed that some of the active compounds, particularly 5i, exhibited a strong binding capability to TMV-CP or CMV-CP. This study revealed that anthranilic diamide derivatives containing moieties of trifluoromethylpyridine and hydrazone could be used as novel antiviral agents for controlling the plant viruses.
Synthetic Route of 41468-25-1, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 41468-25-1.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem