In an article, author is Chaudhary, Kaushik P., once mentioned the application of 628-13-7, Category: pyridine-derivatives, Name is Pyridinehydrochloride, molecular formula is C5H6ClN, molecular weight is 115.56, MDL number is MFCD00012802, category is pyridine-derivatives. Now introduce a scientific discovery about this category.
Coordination behavior of succinylsulfathiazole – Crystal structure of [Cu(SST)(center dot)(Pyridine)(3 center dot)H2O](n), DNA interaction and cytotoxic studies
Mononuclear copper complex of succinylsulfathiazole has been synthesized and characterized using relevant spectroscopic and X-ray diffraction techniques. EPR data and X-ray structural analysis confirmed that Cu(II) ion exhibits an intermediate geometry between trigonal and square bipyramid. Succinylsulfathiazole (SST) ligand behaves as a head-to-tail bridging moiety linking two metal (Cu) cations via carbonyl oxygen and thiazolate nitrogen atom, resulting one dimensional polymeric chain running along [010] direction. In the mononuclear copper complex formulated as [Cu(SST)(center dot)(Pyridine)(3 center dot)H2O](n), three nitrogen atoms of three secondary ligand pyridines coordinated to copper at the equatorial plane, the fourth coordination of distorted pentadentate copper is due to thiazolate nitrogen (N3) occupying the apical position and carbonyl oxygen (O1) of SST ligand at x + 1/2, y-1/2, z-1/2 remaining at fifth coordination site completes the coordination sphere of copper. The inversely related Cu-SST molecular complexes are held together by pair of N-H center dot center dot center dot O dimer forming R-2(2) (14) graph set motif which are further connected by water oxygen (O6) via O-H center dot center dot center dot O interactions. Quantitative contributions of intermolecular interactions are worked out using Hirshfeld surface (HS) and 2D fingerprint plots. Lipophilicity index (Log P), correlates well with the% contribution of C-H center dot center dot center dot pi interaction. To evaluate the binding capabilities and binding mode of molecular complex with CT-DNA, absorption study and viscosity measurement are carried out, confirming the intercalation mode of binding which is further supported by molecular docking studies. In vitro cytotoxicity screening of the complex have been performed on zoological species Artemia cyst. (C) 2020 Elsevier B.V. All rights reserved.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem