Synthetic Route of 211915-84-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 211915-84-3, Name is Ethyl 3-(2-(((4-cyanophenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate, SMILES is O=C(OCC)CCN(C1=NC=CC=C1)C(C2=CC=C3N(C)C(CNC4=CC=C(C#N)C=C4)=NC3=C2)=O, belongs to pyridine-derivatives compound. In a article, author is Ali, Eslam M. H., introduce new discover of the category.
Design, synthesis and anti-inflammatory activity of imidazol-5-yl pyridine derivatives as p38 alpha/MAPK14 inhibitor
P38 alpha VMAPK14 is intracellular signalling regulator involved in biosynthesis of inflammatory mediator cytokines (TNF-alpha, IL-1, IL-6, and IL-1b), which induce the production of inflammatory proteins (iNOS, NF-kappa B, and COX-2). In this study, drug repurposing strategies were followed to repositioning of a series of B-RAF(V600E) imidazol-5-yl pyridine inhibitors to inhibit P38a kinase. A group 25 reported P38a kinase inhibitors were used to build a pharmacophore model for mapping the target compounds and proving their affinity for binding in P38a active site. Target compounds were evaluated for their potency against P38a kinase, compounds 1 la and 11d were the most potent inhibitors (IC50 = 47 nM and 45 nM, respectively). In addition, compound 11d effectively inhibited the production of pminflammatory cytokines TNF-alpha, 1L-6, and 1L-1 beta in LPS-induced RAW 264.7 macrophages with IC50 values of 78.03 mu M, 17.6 nM and 82.15 nM, respectively. The target compounds were tested for their anti-inflammatory activity by detecting the reduction of Nitric oxide (NO) and prostaglandin (PGE2) production in LPS-stimulated RAW 264.7 macrophages. Compound 11d exhibited satisfied inhibitory activity of the production of PGE2 and NO with IC(50 )values of 0.29 mu M and 0.61 mu M, respectively. Molecular dynamics simulations of the most potent inhibitor 11d were carried out to illustrate its conformational stability in the binding site of P38a kinase.
Synthetic Route of 211915-84-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 211915-84-3.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem