Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Formula: C6H5N3O, 6969-71-7, Name is [1,2,4]Triazolo[4,3-a]pyridin-3(2H)-one, SMILES is O=C1NN=C2C=CC=CN21, belongs to pyridine-derivatives compound. In a document, author is Chavan, Subhash P., introduce the new discover.
Enantioselective Formal Total Synthesis of (-)-Quinagolide
The enantioselective formal total synthesis of (-)-quinagolide has been accomplished in a linear sequence of 8 purification steps from pyridine. The key steps are (a) organocatalyzed Diets-Alder reaction for fixing all three stereocenters on piperidine ring; (b) protecting group enabled deoxygenation of isoquinuclidine skeleton under Birch reduction condition; (c) Lewis acid (TiCl4) catalyzed intramolecular Friedel-Crafts cyclization of dicarboxylic acid; and (d) one-pot diastereoselective ketone reduction-intramolecular cyclization to form oxazolidinone which enables trans-geometry installation. During the course of the synthesis, an interesting reductive cleavage of the C-N bond in the electron-deficient isoquinuclidine skeleton under the Birch reduction conditions has been observed. This is the first synthetic effort to access the core skeleton of (-)-quinagolide.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 6969-71-7 is helpful to your research. Formula: C6H5N3O.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem