Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.3731-51-9, Name is Pyridin-2-ylmethanamine, SMILES is NCC1=NC=CC=C1, belongs to pyridine-derivatives compound. In a document, author is Sugiyama, Shuichi, introduce the new discover, Recommanded Product: Pyridin-2-ylmethanamine.
Discovery of novel HIV-1 integrase-LEDGF/p75 allosteric inhibitors based on a pyridine scaffold forming an intramolecular hydrogen bond
We have discovered HIV-1 novel integrase-LEDGF/p75 allosteric inhibitors (INLAIs) based on a pyridine scaffold forming an intramolecular hydrogen bond. Scaffolds containing a pyridine moiety have been studied extensively and we have already reported that substituents extending from the C1 position contributed to the antiviral potency. In this study, we designed a new pyridine scaffold 2 with a substituent at the C1 position. Interestingly, during attempts at optimization, we found that the direction of the C1 substituents with an intramolecular hydrogen bond contributed to the antiviral potency. Compound 34f exhibited better antiviral potency against WT and the T174I mutant (EC50 (WT) = 6.6 nM, EC50 (T174I) = 270 nM) than BI 224436 (EC50 (WT) = 22 nM, EC50 (T174I) > 5000 nM).
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 3731-51-9. Recommanded Product: Pyridin-2-ylmethanamine.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem