Application of 5223-06-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 5223-06-3, Name is 2-(5-Ethylpyridin-2-yl)ethanol, SMILES is CCC1=CN=C(CCO)C=C1, belongs to pyridine-derivatives compound. In a article, author is Macha, Baswaraju, introduce new discover of the category.
Molecular hybridization based design and synthesis of new benzo[5,6]chromeno[2,3-b]-quinolin-13(14H)-one analogs as cholinesterase inhibitors
A Series of new tacrine analogs were designed, synthesized, characterized by respective spectral data and evaluated for cholinesterase inhibitory activity to be useful in Alzheimer’s disease. Most of the synthesized compounds showed good in vitro inhibitory activities toward acetyl cholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. Among the compounds, 6i, 6o and 6r with increased saturated carboxylic ring size attached to the pyridine moiety and having 3,4-dihydroxy, 3,4,5-trimethoxy substituents on the aromatic ring attached at the stereogenic center have shown equal potency to that of tacrine with IC(50)values 0.65 +/- 0.06, 1.32 +/- 0.02 and 0.85 +/- 0.05, 1.65 +/- 0.12 and 0.92 +/- 0.03, 1.91 +/- 0.12 mu M against AChE and BuChE, respectively. Standard drug tacrine exhibited IC50 values of 0.47 +/- 0.02 and 0.65 +/- 0.08, while Donepezil showed IC50 0.71 +/- 0.06 and 0.31 +/- 0.04 mu M against AChE and BuChE, respectively. Docking studies of all the molecules disclosed close hydrogen bond interactions with the binding site.
Application of 5223-06-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 5223-06-3.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem